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Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells

The use of embryonic stem cells for cell-replacement therapy in diseases like diabetes mellitus requires methods to control the development of multipotent cells. We report that treatment of mouse embryonic stem cells with inhibitors of phosphoinositide 3-kinase, an essential intracellular signaling...

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Main Authors: Hori, Yuichi, Rulifson, Ingrid C., Tsai, Bernette C., Heit, Jeremy J., Cahoy, John D., Kim, Seung K.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2002
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC138572/
https://ncbi.nlm.nih.gov/pubmed/12441403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.252618999
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