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Structure of the extracellular domains of the human interleukin-6 receptor α-chain

Dysregulated production of IL-6 and its receptor (IL-6R) are implicated in the pathogenesis of multiple myeloma, autoimmune diseases and prostate cancer. The IL-6R complex comprises two molecules each of IL-6, IL-6R, and the signaling molecule, gp130. Here, we report the x-ray structure (2.4 Å) of t...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Varghese, J. N., Moritz, R. L., Lou, M.-Z., van Donkelaar, A., Ji, H., Ivancic, N., Branson, K. M., Hall, N. E., Simpson, R. J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC138547/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12461182/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.232432399
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