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A crucial role of the thymus in induction by the lprcg gene of lymphadenopathy with autoimmunity in the mouse.

The new mutation at the lpr locus, lprcg, induces massive lymphoproliferation characterized by the selective expansion of CD4-, CD8-, B220+, Thy-1+ cells or double-negative T lymphocytes and production of autoantibodies as does lpr. The thymus is necessary for the induction of anomalous double-negat...

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Detalhes bibliográficos
Main Authors: Matsuzawa, A, Moriyama, T, Ogata, Y, Katagiri, T, Kimura, M
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1384851/
https://ncbi.nlm.nih.gov/pubmed/1592441
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