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In vitro desensitization to lipopolysaccharide suppresses tumour necrosis factor, interleukin-1 and interleukin-6 gene expression in a similar fashion.

Like blood monocytes, the human monocytic cell line Mono Mac 6 can be stimulated by lipopolysaccharide (LPS) at 1 microgram/ml to produce high levels of cytokines. When Mono Mac 6 cells are stimulated for 4-6 hr at 1 x 10(6)/ml, supernatants contain tumour necrosis factor (TNF) at an average of 60 U...

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Autors principals: Ziegler-Heitbrock, H W, Blumenstein, M, Käfferlein, E, Kieper, D, Petersmann, I, Endres, S, Flegel, W A, Northoff, H, Riethmüller, G, Haas, J G
Format: Artigo
Idioma:Inglês
Publicat: 1992
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1384704/
https://ncbi.nlm.nih.gov/pubmed/1551689
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