Role of CD4 molecule in intrathymic T-cell development.

We have investigated the role of CD4 molecules in intrathymic T-cell repertoire selection. The administration of monoclonal antibody (mAb) to CD4 in organ culture of murine foetal thymus (FTOC) completely inhibited the development of CD4+8- cells, and additional treatment with anti-class II MHC (Ia)...

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Detalhes bibliográficos
Main Authors: Takeuchi, Y, Horiuchi, T, Hamamura, K, Sugimoto, T, Yagita, H, Okumura, K
Formato: Artigo
Idioma:Inglês
Publicado em: 1991
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1384591/
https://ncbi.nlm.nih.gov/pubmed/1836198
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