Comparison of the effects of FK-506, cyclosporin A and rapamycin on IL-2 production.

The immunosuppressive compounds FK-506, cyclosporin A (CsA) and rapamycin inhibit both the human and mouse mixed lymphocyte reactions (MLR) with IC50s of 2-5 x 10(-10) M for FK-506 and rapamycin and 10(-8) M for CsA. FK-506 and CsA were also potent inhibitors of A23187/PMA-stimulated IL-2 production...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Henderson, D J, Naya, I, Bundick, R V, Smith, G M, Schmidt, J A
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 1991
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1384549/
https://ncbi.nlm.nih.gov/pubmed/1715317
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