Critical role of the C-terminus in the biological activities of human tumour necrosis factor-alpha

Alterations of the C-terminal amino acid sequence of human tumour necrosis factor-alpha (hTNF-α) caused significant changes in its biological activity. Thus shortening of the C-terminus by removal of two or three amino acids led to a very marked loss of cytotoxic activity. Other, more subtle changes...

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Main Authors:	Gase, K., Korobko, V. G., Wisniewski, H. G., Le, J., Dobrynin, V. N., Filippov, S. A., Gutsche, W., Maksimova, Y. N., Schlott, B., Shingarova, L. N., Vilcek, J., Behnke, D.
Format:	Artigo
Sprog:	Inglês
Udgivet:	1990
Fag:	Articles
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC1384434/ https://ncbi.nlm.nih.gov/pubmed/2269475
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Critical role of the C-terminus in the biological activities of human tumour necrosis factor-alpha

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