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Critical role of the C-terminus in the biological activities of human tumour necrosis factor-alpha
Alterations of the C-terminal amino acid sequence of human tumour necrosis factor-alpha (hTNF-α) caused significant changes in its biological activity. Thus shortening of the C-terminus by removal of two or three amino acids led to a very marked loss of cytotoxic activity. Other, more subtle changes...
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Main Authors: | , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
1990
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1384434/ https://ncbi.nlm.nih.gov/pubmed/2269475 |
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