Presensitization by skin grafting from major histocompatibility complex class I or major histocompatibility complex class II deficient mice identifies class I antigens as inducers of allosensitization.

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• The Use of MHC Class I or Class II “Knock Out” Mice to Investigate the Role of These Antigens in Allosensitization
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• Heterogenous graft rejection pathways in class I major histocompatibility complex-disparate combinations and their differential susceptibility to immunomodulation induced by intravenous presensitization with relevant alloantigens
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• The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice.
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• Rejection of skin allografts by indirect allorecognition of donor class I major histocompatibility complex peptides
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