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Stem-cell factor, the kit ligand, induces direct degranulation of rat peritoneal mast cells in vitro and in vivo: dependence of the in vitro effect on period of culture and comparisons of stem-cell factor with other mast cell-activating agents.
We report that stem-cell factor (SCF), the ligand of the receptor encoded by the c-kit proto-oncogene, is a potent activator of degranulation of rat peritoneal mast cells in vitro and in vivo. Freshly isolated, purified mast cells were relatively unresponsive to SCF (4-500 ng/ml) but progressively a...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
1995
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1383947/ https://ncbi.nlm.nih.gov/pubmed/8550081 |
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