U7 snRNA mutations in Drosophila block histone pre-mRNA processing and disrupt oogenesis

Metazoan replication-dependent histone mRNAs are not polyadenylated, and instead terminate in a conserved stem–loop structure generated by an endonucleolytic cleavage involving the U7 snRNP, which interacts with histone pre-mRNAs through base-pairing between U7 snRNA and a purine-rich sequence in th...

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Main Authors: GODFREY, ASHLEY C., KUPSCO, JEREMY M., BURCH, BRANDON D., ZIMMERMAN, RYAN M., DOMINSKI, ZBIGNIEW, MARZLUFF, WILLIAM F., DURONIO, ROBERT J.
Format: Artigo
Language:Inglês
Published: Copyright 2006 by RNA Society 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1383579/
https://ncbi.nlm.nih.gov/pubmed/16495235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2270406
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