Does tumorigenesis select for or against mutations of the DNA repair-associated genes BRCA2 and MRE11?: Considerations from somatic mutations in microsatellite unstable (MSI) gastrointestinal cancers

BACKGROUND: The BRCA2 and MRE11 proteins participate in the repair of double-strand DNA breaks by homologous recombination. Germline BRCA2 mutations predispose to ovarian, breast and pancreatic cancer, while a germline MRE11 mutation is associated with an ataxia telangiectasia-like disorder. Somatic...

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Detalhes bibliográficos
Main Authors: van der Heijden, Michiel S, Brody, Jonathan R, Elghalbzouri-Maghrani, Elhaam, Zdzienicka, Malgorzata Z, Kern, Scott E
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1382246/
https://ncbi.nlm.nih.gov/pubmed/16417627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2156-7-3
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