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Sequential boundaries approach in clinical trials with unequal allocation ratios

BACKGROUND: In clinical trials, both unequal randomization design and sequential analyses have ethical and economic advantages. In the single-stage-design (SSD), however, if the sample size is not adjusted based on unequal randomization, the power of the trial will decrease, whereas with sequential...

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Hlavní autoři: Jafari, Peyman, Ayatollahi, Seyyed Mohammad Taghi, Behboodian, Javad
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2006
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1382245/
https://ncbi.nlm.nih.gov/pubmed/16412232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2288-6-1
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