Sodium valproate acutely inhibits lamotrigine metabolism.

Concomitant administration of sodium valproate (VPA) reduced lamotrigine (LTG) total clearance by approximately 21% and increased elimination half-life and AUC. Reduced elimination occurred acutely within the first hour. Renal elimination of LTG was not impaired. The most probable explanation for th...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yuen, A W, Land, G, Weatherley, B C, Peck, A W
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1992
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1381438/
https://ncbi.nlm.nih.gov/pubmed/1524964
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