Human and mouse liver coumarin 7-hydroxylases do not metabolize warfarin in vitro.

1. The contribution of human P450 2A6 and mouse P450 2a-5 isoenzymes, both highly active in coumarin 7-hydroxylation, to the metabolism of warfarin was studied in several in vitro systems with human and mouse liver preparations. 2. The reconstituted P450 2a-5 purified from DBA/2 mouse liver did not...

Full description

Saved in:
Bibliographic Details
Main Authors: Honkakoski, P, Arvela, P, Juvonen, R, Lang, M A, Kairaluoma, M, Pelkonen, O
Format: Artigo
Language:Inglês
Published: 1992
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1381282/
https://ncbi.nlm.nih.gov/pubmed/1576054
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items