Deciphering the Ancient and Complex Evolutionary History of Human Arylamine N-Acetyltransferase Genes

The human N-acetyltransferase genes NAT1 and NAT2 encode two phase-II enzymes that metabolize various drugs and carcinogens. Functional variability at these genes has been associated with adverse drug reactions and cancer susceptibility. Mutations in NAT2 leading to the so-called slow-acetylation ph...

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Main Authors: Patin, Etienne, Barreiro, Luis B., Sabeti, Pardis C., Austerlitz, Frédéric, Luca, Francesca, Sajantila, Antti, Behar, Doron M., Semino, Ornella, Sakuntabhai, Anavaj, Guiso, Nicole, Gicquel, Brigitte, McElreavey, Ken, Harding, Rosalind M., Heyer, Evelyne, Quintana-Murci, Lluís
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Human Genetics 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1380286/
https://ncbi.nlm.nih.gov/pubmed/16416399
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