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Calcium channel antagonists and cyclosporine metabolism: in vitro studies with human liver microsomes.

The effects of four Ca2+ channel antagonists on the metabolism of cyclosporine (CsA) by human liver microsomes (n = 4) in vitro have been examined. Nicardipine produced marked inhibition of both M17 and M21 (IC50 = 7.0 microM) formation. In contrast nifedipine produced less than 20% inhibition of M1...

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Bibliografische gegevens
Hoofdauteurs: Tjia, J F, Back, D J, Breckenridge, A M
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1989
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1379957/
https://ncbi.nlm.nih.gov/pubmed/2789931
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