Effect of liver disease on dextromethorphan oxidation capacity and phenotype: a study in 107 patients.

1. The O-demethylation of dextromethorphan to dextrorphan exhibits a genetically-controlled polymorphism, co-segregating with that of debrisoquine hydroxylation. Dextromethorphan has been proposed as a test compound to assess drug oxidation polymorphism. 2. We studied the effects of liver disease of...

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Main Authors: Larrey, D, Babany, G, Tinel, M, Freneaux, E, Amouyal, G, Habersetzer, F, Letteron, P, Pessayre, D
Format: Artigo
Jezik:Inglês
Izdano: 1989
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1379948/
https://ncbi.nlm.nih.gov/pubmed/2789923
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