Detection of pseudouridine and other modifications in tRNA by cyanoethylation and MALDI mass spectrometry

Mass spectrometry plays a central role in the characterisation of modified nucleotides, but pseudouridine is a mass-silent post-transcriptional modification and hence not detectable by direct mass spectrometric analysis. We show by the use of matrix-assisted laser desorption/ionisation (MALDI) mass...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Mengel-Jørgensen, Jonas, Kirpekar, Finn
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 2002
Soggetti:	NAR Methods Online
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137990/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12466567/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gnf135
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