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Coupling of c-Src to large conductance voltage- and Ca(2+)-activated K(+) channels as a new mechanism of agonist-induced vasoconstriction

The voltage-dependent and Ca(2+)-activated K(+) channel (MaxiK, BK) and the cellular proto-oncogene pp60(c-Src) (c-Src) are abundant proteins in vascular smooth muscle. The role of MaxiK channels as a vasorelaxing force is well established, but their role in vasoconstriction is unclear. Because Src...

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Autors principals: Alioua, Abderrahmane, Mahajan, Aman, Nishimaru, Kazuhide, Zarei, Masoud M., Stefani, Enrico, Toro, Ligia
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2002
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC137922/
https://ncbi.nlm.nih.gov/pubmed/12391293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.222348099
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