Efficient production by sperm-mediated gene transfer of human decay accelerating factor (hDAF) transgenic pigs for xenotransplantation

A large number of hDAF transgenic pigs to be used for xenotransplantation research were generated by using sperm-mediated gene transfer (SMGT). The efficiency of transgenesis obtained with SMGT was much greater than with any other method. In the experiments reported, up to 80% of pigs had the transg...

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Hlavní autoři: Lavitrano, Marialuisa, Bacci, Maria Laura, Forni, Monica, Lazzereschi, Davide, Di Stefano, Carla, Fioretti, Daniela, Giancotti, Paola, Marfé, Gabriella, Pucci, Loredana, Renzi, Luigina, Wang, Hongjun, Stoppacciaro, Antonella, Stassi, Giorgio, Sargiacomo, Massimo, Sinibaldi, Paola, Turchi, Valeria, Giovannoni, Roberto, Della Casa, Giacinto, Seren, Eraldo, Rossi, Giancarlo
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2002
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC137866/
https://ncbi.nlm.nih.gov/pubmed/12393815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.222550299
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