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Linkage-disequilibrium mapping of disease genes by reconstruction of ancestral haplotypes in founder populations.

Linkage disequilibrium (LD) mapping may be a powerful means for genome screening to identify susceptibility loci for common diseases. A new statistical approach for detection of LD around a disease gene is presented here. This method compares the distribution of haplotypes in affected individuals ve...

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Autores principales: Service, S K, Lang, D W, Freimer, N B, Sandkuijl, L A
Formato: Artigo
Lenguaje:Inglês
Publicado: 1999
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1377917/
https://ncbi.nlm.nih.gov/pubmed/10330361
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