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Targeting the Mycobacterium tuberculosis 30/32-kDa mycolyl transferase complex as a therapeutic strategy against tuberculosis: Proof of principle by using antisense technology

We have investigated the effect of sequence-specific antisense phosphorothioate-modified oligodeoxyribonucleotides (PS-ODNs) targeting different regions of each of the 30/32-kDa protein complex (antigen 85 complex) encoding genes on the multiplication of Mycobacterium tuberculosis. Single PS-ODNs to...

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Detalhes bibliográficos
Main Authors: Harth, Günter, Horwitz, Marcus A., Tabatadze, David, Zamecnik, Paul C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC137765/
https://ncbi.nlm.nih.gov/pubmed/12427974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.242612299
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