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In vivo dynamics of T cell activation, proliferation, and death in HIV-1 infection: Why are CD4(+) but not CD8(+) T cells depleted?

Deuterated glucose labeling was used to measure the in vivo turnover of T lymphocytes. A realistic T cell kinetic model, with populations of resting and activated T cells, was fitted to d-glucose labeling data from healthy and HIV-1-infected individuals before and after antiretroviral treatment. Our...

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Autori principali: Ribeiro, Ruy M., Mohri, Hiroshi, Ho, David D., Perelson, Alan S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2002
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC137758/
https://ncbi.nlm.nih.gov/pubmed/12434018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.242358099
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