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An allelic series of mutations in Smad2 and Smad4 identified in a genotype-based screen of N-ethyl-N- nitrosourea-mutagenized mouse embryonic stem cells
Using selectable genes as proof of principle, a new high-throughput genotype-based mutation screen in mouse embryonic stem (ES) cells was developed [Chen et al. (2002) Nat. Genet. 24, 314–317]. If expanded to nonselectable genes, this approach would allow one to proceed quickly from sequence to whol...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2002
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC137753/ https://ncbi.nlm.nih.gov/pubmed/12432092 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.242474199 |
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