Measurement in vivo of proliferation rates of slow turnover cells by (2)H(2)O labeling of the deoxyribose moiety of DNA

We describe here a method for measuring DNA replication and, thus, cell proliferation in slow turnover cells that is suitable for use in humans. The technique is based on the incorporation of (2)H(2)O into the deoxyribose (dR) moiety of purine deoxyribonucleotides in dividing cells. For initial vali...

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Bibliografiske detaljer
Main Authors: Neese, R. A., Misell, L. M., Turner, S., Chu, A., Kim, J., Cesar, D., Hoh, R., Antelo, F., Strawford, A., McCune, J. M., Christiansen, M., Hellerstein, M. K.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC137719/
https://ncbi.nlm.nih.gov/pubmed/12424339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.232551499
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