Dating the origin of the CCR5-Delta32 AIDS-resistance allele by the coalescence of haplotypes.

The CCR5-Delta32 deletion obliterates the CCR5 chemokine and the human immunodeficiency virus (HIV)-1 coreceptor on lymphoid cells, leading to strong resistance against HIV-1 infection and AIDS. A genotype survey of 4,166 individuals revealed a cline of CCR5-Delta32 allele frequencies of 0%-14% acro...

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Autori principali: Stephens, J C, Reich, D E, Goldstein, D B, Shin, H D, Smith, M W, Carrington, M, Winkler, C, Huttley, G A, Allikmets, R, Schriml, L, Gerrard, B, Malasky, M, Ramos, M D, Morlot, S, Tzetis, M, Oddoux, C, di Giovine, F S, Nasioulas, G, Chandler, D, Aseev, M, Hanson, M, Kalaydjieva, L, Glavac, D, Gasparini, P, Kanavakis, E, Claustres, M, Kambouris, M, Ostrer, H, Duff, G, Baranov, V, Sibul, H, Metspalu, A, Goldman, D, Martin, N, Duffy, D, Schmidtke, J, Estivill, X, O'Brien, S J, Dean, M
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1998
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1377146/
https://ncbi.nlm.nih.gov/pubmed/9585595
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