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Linkage disequilibrium and gene mapping: an empirical least-squares approach.
This paper proposes a novel approach for fine-scale mapping of disease genes that is based on the well-known linkage-disequilibrium parameter delta. Using a very simple, very general model, I show how delta can be interpreted in terms of identity-by-descent probabilities. The value of delta follows...
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
1998
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1376821/ https://ncbi.nlm.nih.gov/pubmed/9490574 |
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