The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factor

BACKGROUND: Huntington's disease (HD) pathogenesis is due to an expanded polyglutamine tract in huntingtin, but the specificity of neuronal loss compared with other polyglutamine disorders also implies a role for the protein's unknown inherent function. Huntingtin is moderately conserved, with 10 HE...

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Publicado no:	BMC Neurosci
Principais autores:	Takano, Hiroki, Gusella, James F
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2002
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137586/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12379151/ https://ncbi.nlm.nih.govhttps://doi.org/10.1186/1471-2202-3-15
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