Dobzhansky–Muller incompatibilities in protein evolution
We study fitness landscape in the space of protein sequences by relating sets of human pathogenic missense mutations in 32 proteins to amino acid substitutions that occurred in the course of evolution of these proteins. On average, ≈10% of deviations of a nonhuman protein from its human ortholog are...
Uloženo v:
| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2002
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137512/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12403824/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.232565499 |
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