Synthetic small inhibiting RNAs: Efficient tools to inactivate oncogenic mutations and restore p53 pathways

Single base pair mutations that alter the function of tumor suppressor genes and oncogenes occur frequently during oncogenesis. The guardian of the genome, p53, is inactivated by point mutation in more than 50% of human cancers. Synthetic small inhibiting RNAs (siRNAs) can suppress gene expression i...

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Detaylı Bibliyografya
Asıl Yazarlar: Martinez, Luis Alfonso, Naguibneva, Irina, Lehrmann, Heike, Vervisch, Arlette, Tchénio, Thierry, Lozano, Guillermina, Harel-Bellan, Annick
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2002
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC137507/
https://ncbi.nlm.nih.gov/pubmed/12403821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.222406899
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