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Synthetic small inhibiting RNAs: Efficient tools to inactivate oncogenic mutations and restore p53 pathways

Single base pair mutations that alter the function of tumor suppressor genes and oncogenes occur frequently during oncogenesis. The guardian of the genome, p53, is inactivated by point mutation in more than 50% of human cancers. Synthetic small inhibiting RNAs (siRNAs) can suppress gene expression i...

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Main Authors: Martinez, Luis Alfonso, Naguibneva, Irina, Lehrmann, Heike, Vervisch, Arlette, Tchénio, Thierry, Lozano, Guillermina, Harel-Bellan, Annick
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2002
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC137507/
https://ncbi.nlm.nih.gov/pubmed/12403821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.222406899
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