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Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors

The oncoprotein hdm2 ubiquitinates p53, resulting in the rapid degradation of p53 through the ubiquitin (Ub)–proteasome pathway. Hdm2-mediated destabilization and inactivation of p53 are thought to play a critical role in a number of human cancers. We have used an in vitro enzyme assay, monitoring h...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Lai, Zhihong, Yang, Tao, Kim, Young B., Sielecki, Thais M., Diamond, Melody A., Strack, Peter, Rolfe, Mark, Caligiuri, Maureen, Benfield, Pamela A., Auger, Kurt R., Copeland, Robert A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137488/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12407176/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.212428599
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