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Reversion of lethality and growth defects in Fatiga oxygen-sensor mutant flies by loss of Hypoxia-Inducible Factor-α/Sima

Hypoxia-Inducible Factor (HIF) prolyl hydroxylase domains (PHDs) have been proposed to act as sensors that have an important role in oxygen homeostasis. In the presence of oxygen, they hydroxylate two specific prolyl residues in HIF-α polypeptides, thereby promoting their proteasomal degradation. So...

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Detalhes bibliográficos
Main Authors: Centanin, Lázaro, Ratcliffe, Peter J, Wappner, Pablo
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1371028/
https://ncbi.nlm.nih.gov/pubmed/16179946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400528
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