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Reversion of lethality and growth defects in Fatiga oxygen-sensor mutant flies by loss of Hypoxia-Inducible Factor-α/Sima

Hypoxia-Inducible Factor (HIF) prolyl hydroxylase domains (PHDs) have been proposed to act as sensors that have an important role in oxygen homeostasis. In the presence of oxygen, they hydroxylate two specific prolyl residues in HIF-α polypeptides, thereby promoting their proteasomal degradation. So...

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Sonraí Bibleagrafaíochta
Main Authors: Centanin, Lázaro, Ratcliffe, Peter J, Wappner, Pablo
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2005
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1371028/
https://ncbi.nlm.nih.gov/pubmed/16179946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400528
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