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Distinct contributions of KH domains to substrate binding affinity of Drosophila P-element somatic inhibitor protein

Drosophila P-element somatic inhibitor protein (PSI) regulates splicing of the P-element transposase pre-mRNA by binding a pseudo-splice site upstream of the authentic splice site using four tandem KH-type RNA binding motifs. While the binding domains and specificity of PSI have been established, li...

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Autores principales: CHMIEL, NIKOLAS H., RIO, DONALD C., DOUDNA, JENNIFER A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Copyright 2006 by RNA Society 2006
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370908/
https://ncbi.nlm.nih.gov/pubmed/16428607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2175706
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