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Unrestricted accessibility of short oligonucleotides to RNA
The propensity of RNA to fold into higher-order structures poses a major barrier to the use of short probes (<15 nucleotides) by preventing their accessibility. Introduction of the pseudo-complementary bases 2-aminoadenine (nA) and 2-thiouracil (sU) and the destabilizing base 7-deazaguanine (cG)...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Copyright 2005 by RNA Society
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1370827/ https://ncbi.nlm.nih.gov/pubmed/16120834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2670705 |
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