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Mutations in the middle domain of yeast poly(A) polymerase affect interactions with RNA but not ATP

The eukaryotic poly(A) polymerase (PAP) is responsible for the posttranscriptional extension of mRNA 3′ ends by the addition of a poly(A) tract. The recently published three-dimensional structures of yeast and bovine PAPs have made a more directed biochemical analysis of this enzyme possible. Based...

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Autors principals: ZHELKOVSKY, ALEXANDER, HELMLING, STEFFEN, BOHM, ANDREW, MOORE, CLAIRE
Format: Artigo
Idioma:Inglês
Publicat: Copyright 2004 by RNA Society 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370545/
https://ncbi.nlm.nih.gov/pubmed/15037764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.5238704
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