Preexisting Immunity to Adenovirus in Rhesus Monkeys Fails To Prevent Vector-Induced Toxicity

In an earlier study we evaluated innate immune responses to a first-generation adenoviral vector infused into the portal vein of rhesus monkeys who had never been exposed to adenovirus previously. In these animals, the systemic administration of E1/E3-deleted adenoviral vectors resulted in immediate...

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Autors principals: Varnavski, Andrei N., Zhang, Yi, Schnell, Michael, Tazelaar, John, Louboutin, Jean-Pierre, Yu, Qian-Chun, Bagg, Adam, Gao, Guang-ping, Wilson, James M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2002
Matèries:
Gene Therapy
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC137042/
https://ncbi.nlm.nih.gov/pubmed/11991999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.11.5711-5719.2002
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