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De novo synthesis of minus strand RNA by the rotavirus RNA polymerase in a cell-free system involves a novel mechanism of initiation.

The replicase activity of rotavirus open cores has been used to study the synthesis of (-) strand RNA from viral (+) strand RNA in a cell-free replication system. The last 7 nt of the (+) strand RNA, 5'-UGUGACC-3', are highly conserved and are necessary for efficient (-) strand synthesis i...

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Bibliografiske detaljer
Main Authors: Chen, D, Patton, J T
Format: Artigo
Sprog:Inglês
Udgivet: 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370016/
https://ncbi.nlm.nih.gov/pubmed/11073221
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