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An unusual structure formed by antisense-target RNA binding involves an extended kissing complex with a four-way junction and a side-by-side helical alignment.

The antisense RNA CopA binds to the leader region of the repA mRNA (target: CopT). Previous studies on CopA-CopT pairing in vitro showed that the dominant product of antisense RNA-mRNA binding is not a full RNA duplex. We have studied here the structure of CopA-CopT complex, combining chemical and e...

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Detalles Bibliográficos
Main Authors: Kolb, F A, Malmgren, C, Westhof, E, Ehresmann, C, Ehresmann, B, Wagner, E G, Romby, P
Formato: Artigo
Idioma:Inglês
Publicado: 2000
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1369915/
https://ncbi.nlm.nih.gov/pubmed/10744017
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