Identification of VP1/2A and 2C as Virulence Genes of Hepatitis A Virus and Demonstration of Genetic Instability of 2C

Fourteen different chimeric virus genomes were constructed from two infectious cDNA clones encoding a virulent and an attenuated isolate, respectively, of the HM175 strain of hepatitis A virus. The ability of each recombinant virus to infect tamarins and to cause acute hepatitis was determined. Comp...

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Bibliographische Detailangaben
Hauptverfasser: Emerson, Suzanne U., Huang, Ying K., Nguyen, Hanh, Brockington, Alicia, Govindarajan, Sugantha, St. Claire, Marisa, Shapiro, Max, Purcell, Robert H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2002
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC136972/
https://ncbi.nlm.nih.gov/pubmed/12163575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.17.8551-8559.2002
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