Probing accessible sites for ribozymes on human acetylcholinesterase RNA.

In order to design ribozymes for the efficient cleavage of a human acetylcholinesterase (AChE) in vitro transcript, a completely randomized decadeoxyribonucleotide (dN10) was used in conjunction with RNase H to identify suitable sites for annealing. Based on the observed cleavage pattern, ribozymes...

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Bibliographic Details
Main Authors: Birikh, K R, Berlin, Y A, Soreq, H, Eckstein, F
Format: Artigo
Language:Inglês
Published: 1997
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1369494/
https://ncbi.nlm.nih.gov/pubmed/9085849
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