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Do mammalian cytochrome P450s show multiple ligand access pathways and ligand channelling?

Understanding substrate binding and product release in cytochrome P450 (CYP) enzymes is important for explaining their key role in drug metabolism, toxicity, xenobiotic degradation and biosynthesis. Here, molecular simulations of substrate and product exit from the buried active site of a mammalian...

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Bibliografski detalji
Glavni autori: Schleinkofer, Karin, Sudarko, Winn, Peter J., Lüdemann, Susanne K., Wade, Rebecca C.
Format: Artigo
Jezik:Inglês
Izdano: 2005
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1369091/
https://ncbi.nlm.nih.gov/pubmed/16028306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400420
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