Hypoxia-inducible factor-1α polymorphisms and TSC1/2 mutations are complementary in head and neck cancers

BACKGROUND: Polymorphisms or mutations in hypoxia inducible factor-1 alpha (HIF-1alpha) that increases its activity and stability under normoxia have recently been identified. Likewise, disruption of the TSC1/TSC2 complex through loss of TSC1 or TSC2 has been shown to result in abnormal accumulation...

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Bibliografische gegevens
Hoofdauteurs: Hebert, Carla, Norris, Kathleen, Parashar, Pallavi, Ord, Robert A, Nikitakis, Nikolaos G, Sauk, John J
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2006
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1369006/
https://ncbi.nlm.nih.gov/pubmed/16412252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-5-3
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