Cell Cycle Arrest by Human Cytomegalovirus 86-kDa IE2 Protein Resembles Premature Senescence

Primary human embryo lung fibroblasts and adult diploid fibroblasts infected by the human cytomegalovirus (HCMV) display β-galactosidase (β-Gal) activity at neutral pH (senescence-associated β-Gal [SA-β-Gal] activity) and overexpression of the plasminogen activator inhibitor type 1 (PAI-1) gene, two...

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Main Authors: Noris, Emanuela, Zannetti, Claudia, Demurtas, Anna, Sinclair, John, De Andrea, Marco, Gariglio, Marisa, Landolfo, Santo
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2002
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC136868/
https://ncbi.nlm.nih.gov/pubmed/12414954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.23.12135-12148.2002
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