Effects of pravastatin and cholestyramine on gonadal and adrenal steroid production in familial hypercholesterolaemia.

1. Adrenal and gonadal steroids are derived from cholesterol, which may be derived from plasma lipoproteins or de novo synthesis. 2. Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate limiting enzyme in cholesterol synthesis, may therefore affect steroidogenesis when u...

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Bibliographic Details
Main Authors: Jay, R H, Sturley, R H, Stirling, C, McGarrigle, H H, Katz, M, Reckless, J P, Betteridge, D J
Format: Artigo
Language:Inglês
Published: 1991
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1368599/
https://ncbi.nlm.nih.gov/pubmed/1958433
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