Genetically Engineered Vesicular Stomatitis Virus in Gene Therapy: Application for Treatment of Malignant Disease

We report here the generation of recombinant vesicular stomatitis virus (VSV) able to produce the suicide gene product thymidine kinase (TK) or cytokine interleukin 4 (IL-4). In vitro cells infected with the engineered viruses expressed remarkably high levels of biologically active TK or IL-4 and sh...

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Autors principals: Fernandez, Marilyn, Porosnicu, Mercedes, Markovic, Dubravka, Barber, Glen N.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2002
Matèries:
Gene Therapy
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC136833/
https://ncbi.nlm.nih.gov/pubmed/11752178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.2.895-904.2002
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