Chronic administration of N-acetylcysteine fails to prevent nitrate tolerance in patients with stable angina pectoris.

1. Reduced availability of sulphydryl groups in vascular smooth muscle cells may contribute to the development of tolerance to the action of the organic nitrovasodilators. 2. Eight patients with stable angina were treated with 10 mg of transdermal glyceryl trinitrate per 24 h, together with 400 mg N...

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Bibliografiske detaljer
Main Authors: Hogan, J C, Lewis, M J, Henderson, A H
Format: Artigo
Sprog:Inglês
Udgivet: 1990
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1368247/
https://ncbi.nlm.nih.gov/pubmed/2127226
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