Lack of an Immune Response against the Tetracycline-Dependent Transactivator Correlates with Long-Term Doxycycline-Regulated Transgene Expression in Nonhuman Primates after Intramuscular Injection of Recombinant Adeno-Associated Virus

We previously documented persistent regulation of erythropoietin (Epo) secretion in mice after a single intramuscular (i.m.) injection of a recombinant adeno-associated virus (rAAV) vector harboring both the tetracycline-dependent transactivator (rtTA) and the Epo cDNA (D. Bohl, A. Salvetti, P. Moul...

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Main Authors: Favre, David, Blouin, Véronique, Provost, Nathalie, Spisek, Radec, Porrot, Françoise, Bohl, Delphine, Marmé, Frederic, Chérel, Yan, Salvetti, Anna, Hurtrel, Bruno, Heard, Jean-Michel, Rivière, Yves, Moullier, Philippe
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2002
Teme:
Gene Therapy
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC136781/
https://ncbi.nlm.nih.gov/pubmed/12388721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.22.11605-11611.2002
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