Interaction of Zwitterionic Penicillins with the OmpF Channel Facilitates Their Translocation

To study translocation of β-lactam antibiotics of different size and charge across the outer bacterial membrane, we combine an analysis of ion currents through single trimeric outer membrane protein F (OmpF) porins in planar lipid bilayers with molecular dynamics simulations. Because the size of pen...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Danelon, Christophe, Nestorovich, Ekaterina M., Winterhalter, Mathias, Ceccarelli, Matteo, Bezrukov, Sergey M.
Format: Artigo
Langue:Inglês
Publié: Biophysical Society 2006
Sujets:
Channels, Receptors, and Electrical Signaling
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1367313/
https://ncbi.nlm.nih.gov/pubmed/16339889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.075192
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