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The Fe-CO Bond Energy in Myoglobin: A QM/MM Study of the Effect of Tertiary Structure

The Fe-CO bond dissociation energy (BDE) in myoglobin (Mb) has been calculated with B3LYP quantum mechanics/molecular mechanics methods for 22 different Mb conformations, generated from molecular dynamics simulations. Our average BDE of 8.1 kcal/mol agrees well with experiment and shows that Mb weak...

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Detalhes bibliográficos
Main Authors: Strickland, Nikki, Mulholland, Adrian J., Harvey, Jeremy N.
Formato: Artigo
Idioma:Inglês
Publicado em: Biophysical Society 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1367296/
https://ncbi.nlm.nih.gov/pubmed/16387767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.078097
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